Sleep Study

Pendulum Therapeutics conducted an 8-week open-label study to evaluate the safety and potential benefits of its probiotic supplement, Metabolic Daily, on sleep and related health outcomes in adults experiencing persistent poor sleep. Participants, selected based on self-reported sleep challenges and Oura ring data, took one capsule daily. The study found high compliance and no serious adverse events, with mild gastrointestinal discomfort being the most commonly reported issue, indicating the supplement was generally safe and well-tolerated.

Subjective assessments using validated questionnaires revealed significant improvements in sleep disturbance, fatigue, mental health, and physical health scores. While perceived stress also trended downward, the change was not statistically significant. Objective data from Oura rings showed no major shifts in sleep metrics, though a slight drop in sleep efficiency was observed but deemed clinically insignificant. Overall, the findings suggest that Metabolic Daily may offer meaningful support for individuals struggling with sleep quality and its broader health impacts.